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Likewise, DAYBREAK revealed no treatment benefit on any endpoint, with similar side effects. Biomarker data demonstrated target engagement. Lanabecestat reduced blood Aβ40 and Aβ42 levels by 70 to 80 percent in both trials. CSF Aβ, measured in AMARANTH, dropped by 50 and 73 percent at the low and high doses, respectively.
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