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CSF proteomics pegs 137 proteins that diverge in ADAD mutation carriers along AD continuum. Twelve changed before classical AD biomarkers did. Six—GFAP, NPTX2, PEA15, SMOC1, SMOC2, and TNFRSF1B—collectively predicted mutation status better than did classical AD biomarkers. Measuring more than 6,000 proteins in the cerebrospinal fluid of ...
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