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Drummond agreed. “SMOC1 appears to be one of the most consistent fluid biomarkers of AD,” she wrote. Using machine learning, Shen and colleagues identified nine proteins of the 125 that best identified people who carried an AD mutation. These were SMOC1, SMOC2, NPTX2, CAND1, PPP3CA, PRKCG, TMOD3, TREM1, and UBE2N.
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